期刊
DEVELOPMENT
卷 145, 期 1, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.155929
关键词
Incisor; Stem cells; Sox2; Lgr5; Hierarchy; Morphogenesis; Renewal
资金
- Finnish Doctoral Program in Oral Sciences
- Academy of Finland (Suomen Akatemia)
- National Institutes of Health [R35-DE026602]
In mice, the incisors grow throughout the animal's life, and this continuous renewal is driven by dental epithelial and mesenchymal stem cells. Sox2 is a principal marker of the epithelial stem cells that reside in the mouse incisor stem cell niche, called the labial cervical loop, but relatively little is known about the role of the Sox2(+) stem cell population. In this study, we show that conditional deletion of Sox2 in the embryonic incisor epithelium leads to growth defects and impairment of ameloblast lineage commitment. Deletion of Sox2 specifically in Sox2(+) cells during incisor renewal revealed cellular plasticity that leads to the relatively rapid restoration of a Sox2-expressing cell population. Furthermore, we show that Lgr5-expressing cells are a subpopulation of dental Sox2(+) cells that also arise from Sox2(+) cells during tooth formation. Finally, we show that the embryonic and adult Sox2(+) populations are regulated by distinct signalling pathways, which is reflected in their distinct transcriptomic signatures. Together, our findings demonstrate that a Sox2(+) stem cell population can be regenerated from Sox2(-) cells, reinforcing its importance for incisor homeostasis.
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