期刊
CELL CHEMICAL BIOLOGY
卷 25, 期 2, 页码 194-+出版社
CELL PRESS
DOI: 10.1016/j.chembiol.2017.11.004
关键词
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资金
- People Program (Marie Curie Actions) of the 7th Framework Program of the European Union under REA [600388]
- Agency of Business Competitiveness of the Government of Catalonia, ACCIO
- Wellcome Trust Sir Henry Wellcome Postdoctoral Fellowship [204735/Z/16/Z]
- Cancer Research UK (CRUK) Strategic Project Award [C35696/A23187]
- Institute of Cancer Research (ICR)
- Cancer Research CRUK program grant [C309/A11566]
- CRUK at the ICR
- NHS at Royal Marsden NHS Foundation Trust
- Wellcome Trust [204735/Z/16/Z] Funding Source: Wellcome Trust
- Cancer Research UK [11566, 22897, 25678] Funding Source: researchfish
Chemical probes are essential tools for understanding biological systems and for target validation, yet selecting probes for biomedical research is rarely based on objective assessment of all potential compounds. Here, we describe the Probe Miner: Chemical Probes Objective Assessment resource, capitalizing on the plethora of public medicinal chemistry data to empower quantitative, objective, data-driven evaluation of chemical probes. We assess >1.8 million compounds for their suitability as chemical tools against 2,220 human targets and dissect the biases and limitations encountered. Probe Miner represents a valuable resource to aid the identification of potential chemical probes, particularly when used alongside expert curation.
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