期刊
CANCER SCIENCE
卷 109, 期 2, 页码 317-329出版社
WILEY
DOI: 10.1111/cas.13453
关键词
apoptosis; CASP3; esophageal squamous cell carcinoma; HOXC13; miR-503
类别
资金
- National Natural Science Foundation of China [81172032]
- Jiangsu Provincial Special Program of Medical Science Funding [BL2012030]
- Jiangsu Provincial Science Foundation [BK20161596]
- Jiangsu Provincial Medical Outstanding Talent
- Jiangsu Provincial Medical Youth Talent [QNRC2016657]
- Jiangsu Provincial key research development program [BE2017758]
Esophageal squamous cell carcinoma (ESCC), the dominant subtype of esophageal cancer, is one of the most common digestive tumors worldwide. In this study, we confirmed that HOXC13, a member of the homeobox HOXC gene family, was significantly upregulated in ESCC and its overexpression was associated with poorer clinical characteristics and worse prognosis. Moreover, knockdown of HOXC13 inhibited proliferation and induced apoptosis of ESCC through upregulating CASP3. ChIP analysis revealed that HOXC13 repressed transcription of CASP3 through directly targeting the promotor region of CASP3. We also found that miR-503 downregulated HOXC13, by directly targeting its 3UTR, and inhibited proliferation of ESCC. In conclusion, our study demonstrates that HOXC13, which is directly targeted by miR-503, promotes proliferation and inhibits apoptosis of ESCC through repressing transcription of CASP3.
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