期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 46, 期 -, 页码 11-21出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20170037
关键词
-
资金
- British Heart Foundation (BHF) [PG/16/58/32275, FS/14/7/30574]
- BHF Centre of Research Excellence
- British Heart Foundation [FS/14/7/30574, FS/11/52/29018, PG/16/58/32275] Funding Source: researchfish
MicroRNAs (miRNAs) are small non-coding RNAs of similar to 22 nucleotides, which have increasingly been recognized as potent post-transcriptional regulators of gene expression. MiRNA targeting is defined by the complementarities between positions 2-8 of miRNA 5'-end with generally the 3'-untranslated region of target mRNAs (messenger RNAs). The capacity of miRNAs to simultaneously inhibit many different mRNAs allows for an amplification of biological responses. Hence, miRNAs are extremely attractive targets for therapeutic regulation in several diseases, including cardiovascular. Novel approaches are emerging to identify the miRNA functions in cardiovascular biology processes and to improve miRNA delivery in the heart and vasculature. In the present study, we provide an overview of current studies of miRNA functions in cardiovascular cells by the use of high-content screening. We also discuss the challenge to achieve a safe and targeted delivery of miRNA therapeutics in cardiovascular cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据