4.6 Article

Joint Analysis of Cortical Area and Thickness as a Replacement for the Analysis of the Volume of the Cerebral Cortex

期刊

CEREBRAL CORTEX
卷 28, 期 2, 页码 738-749

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhx308

关键词

cortical gray matter volume; cortical surface area; cortical thickness; nonparametric combination

资金

  1. Research Council of Norway [ES182663]
  2. Central Norway Regional Health Authority [46056610, 46039500]
  3. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (Brazil) (CNPq) [211534/2013-7]
  4. Wellcome Trust [100309/Z/12/Z]
  5. NIH [R21AG050122-01A1, R41AG052246-01, 1K25EB013649-01]
  6. Norwegian National Advisory Unit for Functional MRI [96288]

向作者/读者索取更多资源

Cortical surface area is an increasingly used brain morphology metric that is ontogenetically and phylogenetically distinct from cortical thickness and offers a separate index of neurodevelopment and disease. However, the various existing methods for assessment of cortical surface area from magnetic resonance images have never been systematically compared. We show that the surface area method implemented in FreeSurfer corresponds closely to the exact, but computationally more demanding, mass-conservative (pycnophylactic) method, provided that images are smoothed. Thus, the data produced by this method can be interpreted as estimates of cortical surface area, as opposed to areal expansion. In addition, focusing on the joint analysis of thickness and area, we compare an improved, analytic method for measuring cortical volume to a permutation-based nonparametric combination (NPC) method. We use the methods to analyze area, thickness and volume in young adults born preterm with very low birth weight, and show that NPC analysis is a more sensitive option for studying joint effects on area and thickness, giving equal weight to variation in both of these 2 morphological features.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据