期刊
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
卷 43, 期 1, 页码 84-90出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1068162017010125
关键词
tyrosyl-DNA phosphodiesterase 1; tyrosyl-DNA phosphodiesterase 1 inhibitors; usnic acid
资金
- Russian Scientific Foundation [16-13-10074]
- Russian Science Foundation [16-13-10074] Funding Source: Russian Science Foundation
The synthesis of (+)-usnic acid derivatives is described. The derivatives contain one or two cyano groups, connected to the acetophenone fragment of dibenzofuran core by linkers of different length and character, or some other modifications. The influence of these compounds on the activity of recombinant human tyrosyl-DNA phosphodiesterase 1 and MCF-7 tumor cells' viability has been estimated. The data indicate a distinct dependence of functional characteristics of the compounds on their structure.
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