期刊
ENVIRONMENTAL SCIENCE & TECHNOLOGY
卷 49, 期 7, 页码 4600-4608出版社
AMER CHEMICAL SOC
DOI: 10.1021/es506293t
关键词
-
资金
- National Science Foundation of PR China [21477070, 21377076, 21222701]
- Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20121401110003, 20131401110005]
- Project for Science and Technology Development of Shanxi Province [20120313009-2]
- Shanxi Scholarship Council of China [2012-009]
- Program for the Top Young and Middle-aged Innovative Talents of Higher Learning Institutions of Shanxi (TYMIT) [20120201]
Multiple pollutants, usually at low levels, coexist and may interact in the environment. It is therefore important to analyze the toxicity of mixtures of coexisting chemicals to evaluate the potential ecological risk. Concern regarding the co-occurrence and combined bioeffects of heavy metals and organic insecticides in aquatic settings has existed for many years, but a clear understanding of the interactions between and potential combined toxicity of these chemicals remains elusive. In the present study, the combined effects of the heavy metal nickel (NiSO4) and insect growth regulator buprofezin on the induction of embryo toxicity in zebrafish were assessed. By applying nonlinear regression to the concentrationresponse data with each of the chemicals using the Hill and Langmuir functions and computing the predictions using the model of concentration addition (CA), we confirmed that NiSO4 and buprofezin acted together to produce synergistic embryotoxicity in zebrafish. Subsequently, we further found that the combination of NiSO4 and buprofezin formed a complex that facilitated the uptake of nickel (Ni) and buprofezin by the embryos. Following this, we clarified that an oxidative mechanism of the complex might underlie the synergistic embryotoxicity of NiSO4 and buprofezin.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据