期刊
RUSSIAN CHEMICAL BULLETIN
卷 66, 期 11, 页码 2173-2179出版社
SPRINGER
DOI: 10.1007/s11172-017-1999-x
关键词
N,N-diacetylsialyl chloride; sialylation; dynamic light scattering; chromogenic substrates; phase-transfer catalysis; mesoscale particles; supramers; solution structure; reactivity
资金
- Russian Science Foundation [16-13-10244]
- Russian Science Foundation [16-13-10244] Funding Source: Russian Science Foundation
O-Sialylation of a substituted indolin-3-one under phase-transfer catalysis conditions, which does not occur when N-acetylsialyl chloride is used, proceeds with N,N-diacetylsialyl chloride as the glycosyl donor. A study using dynamic light scattering of solutions of both sialyl chlorides under conditions close to the conditions used for glycosylation showed a difference in the correlation radii of light scattering particles in such solutions. This suggests that the introduction of an additional N-acetyl group into the sialyl chloride significantly alters the structure of the supramers of glycosyl donor, which apparently have an increased accessibility of individual molecules for the attack by a nucleophile, which increases its reactivity.
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