Mortality causes in infectious diseases

Background: Infectious diseases still remain an important cause of death, despite available modern therapeutical approaches. Methods: we performed an observational study, collecting data from patients admitted to Dr. Victor Babes Clinical Hospital for Infectious and Tropical Diseases, Bucharest between January 1st 2014 and December 31st 2015. Results: Overall, 437 deaths were registered, sepsis being the main cause of death, representing 35%. Regarding gender distribution, we observed that sepsis related death was higher in females (52.9%) than males. HIV associated death was recorded in 54 patients. The mean age of death was 37 years CI95% (32.47-40.94), being the youngest age in the study group. Bronchopneumonia associated death represented 12.1% of the total numbers of recorded deaths, occurring mainly in older patients, with an average age of 70 years Cl95% (65.38-74.54). The mortality rate of Clostridium difficile colitis was 3.43%. Central nervous system infections had a mortality rate of 11.8%. The mean age of death was 63 years CI95% (59.13-67.36). Conclusions: First three causes of death were sepsis, HIV related complications and lower respiratory tract infections. Advanced age, immobilisation, underlying cardiac pathology were independent risk factor for mortality in the studied group