期刊
ENVIRONMENTAL SCIENCE & TECHNOLOGY
卷 49, 期 19, 页码 11649-11658出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.est.5b02478
关键词
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资金
- Japan Society for the Promotion of Science (JSPS) for Young Scientists in Japan (DC2) [26.2800]
- KAKENHI [25257403, 26220103]
- Excellent Graduate Schools from the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT)
- [24651010]
- [25701014]
- Grants-in-Aid for Scientific Research [25257403, 14J02800, 25701014, 26220103, 25241013] Funding Source: KAKEN
A fish plasma model (FPM) has been proposed as a screening technique to prioritize potential hazardous pharmaceuticals to wild fish. However, this approach does not account for inter- or intraspecies variability of pharmacokinetic and pharmacodynamic parameters. The present study elucidated the uptake potency (from ambient water), tissue distribution, and biological risk of 20 pharmaceutical and personal care product (PPCP) residues in wild cyprinoid fish inhabiting treated-wastewater-impacted streams. In order to clarify the uncertainty of the FPM for PPCPs, we compared the plasma bioaccumulation factor in the field (BAF(plasma) = measured fish plasma/ambient water concentration ratio) with the predicted plasma bioconcentration factor (BCFplasma = fish plasma predicted by use of theoretical partition coefficients/ambient water concentration ratio) in the actual environment. As a result, the measured maximum BAF(plasma) of inflammatory agents was up to 17 times higher than theoretical BCFplasma values, leading to possible underestimation of toxicological risk on wild fish. When the tissue blood partition coefficients (tissue/blood concentration ratios) of PPCPs were estimated, higher transportability into tissues, especially the brain, was found for psychotropic agents, but brain/plasma ratios widely varied among individual fish (up to 28-fold). In the present study, we provide a valuable data set on the intraspecies variability of PPCP pharmacokinetics, and our results emphasize the importance of determining PPCP concentrations in possible target organs as well as in the blood to assess the risk of PPCPs on wild fish.
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