期刊
RNA
卷 23, 期 12, 页码 1754-1769出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1261/rna.063503.117
关键词
RNA modification; epitranscriptome; disease; detection methods; direct RNA sequencing
资金
- UNSW
- Cancer Council NSW [RG 14-18]
- Human Frontier Science Program [LT000307/2013-L]
- Australian Research Council [DE170100506]
- National Health and Medical Research Council funds [APP1070631]
- Australian Research Council [DE170100506] Funding Source: Australian Research Council
RNA modifications have been historically considered as fine-tuning chemo-structural features of infrastructural RNAs, such as rRNAs, tRNAs, and snoRNAs. This view has changed dramatically in recent years, to a large extent as a result of systematic efforts to map and quantify various RNA modifications in a transcriptome-wide manner, revealing that RNA modifications are reversible, dynamically regulated, far more widespread than originally thought, and involved in major biological processes, including cell differentiation, sex determination, and stress responses. Here we summarize the state of knowledge and provide a catalog of RNA modifications and their links to neurological disorders, cancers, and other diseases. With the advent of direct RNA-sequencing technologies, we expect that this catalog will help prioritize those RNA modifications for transcriptome-wide maps.
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