期刊
RNA BIOLOGY
卷 14, 期 12, 页码 1683-1689出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2017.1361098
关键词
KIT; epithelial-mesenchymal interaction; exosomes; miR-133b-3p; microRNA; salivary gland
资金
- Intramural Research Program of the National Institute of Dental and Craniofacial Research at the National Institutes of Health, USA
- JSPS KAKENHI [JP15K11060, JP15K20370, JP17K08520]
- Sumitomo Foundation, Japan
- Grants-in-Aid for Scientific Research [15K11060, 17K08520] Funding Source: KAKEN
Epithelial-mesenchymal interactions are required to coordinate cell proliferation, patterning, and functional differentiation of multiple cell types in a developing organ. This exquisite coordination is dependent on various secreted molecules that provide developmental signals to mediate these tissue interactions. Recently, it was reported that mature mesenchymal-derived microRNAs (miRNAs) in the fetal mouse salivary gland are loaded into exosomes, and transported to the epithelium where they influence progenitor cell proliferation. The exosomalmi RNAs regulated epithelial expression of genes involved in DNA methylation in progenitor cells to influence morphogenesis. Thus, exosomal miRNAs are mobile genetic signals that cross tissue boundaries within an organ. These findings raise many questions about how miRNA signals are initiated to coordinate organogenesis and whether they are master regulators of epithelial-mesenchymal interactions. The development of therapeutic applications using exosomal miRNAs for the regeneration of damaged adult organs is a promising area of research.
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