期刊
RNA BIOLOGY
卷 14, 期 9, 页码 1232-1240出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2017.1307484
关键词
Drosophila; m(6)A; neurogenesis; RNA modifications; Sex lethal; splicing
资金
- Marie Curie CIG [334288]
- Deutsche Forschungsgemeinschaft (DFG) [SPP1935, RO 4681/4-1]
- European COST action [CA16120]
- Biotechnology and Biological Science Research Council (BBSRC)
RNA modifications are an emerging layer of posttranscriptional gene regulation in eukaryotes. N-6-methyladenosine (m(6)A) is among the most abundant modifications in mRNAs (mRNAs) that was shown to influence many physiological processes from yeast to mammals. Like DNA methylation, m(6)A in mRNA is dynamically regulated. A conserved methyltransferase complex catalyzes the deposition of the methyl group on adenosine, which can be removed by specific classes of demethylases. Furthermore, YTH-domain containing proteins can recognize this modification to mediate m(6)A-dependent activities. Here we review the functions and mechanisms of the main m(6)A players with a particular focus on Drosophila melanogaster.
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