Thinking Clearly About Correlations and Causation: Graphical Causal Models for Observational Data

Correlation does not imply causation; but often, observational data are the only option, even though the research question at hand involves causality. This article discusses causal inference based on observational data, introducing readers to graphical causal models that can provide a powerful tool for thinking more clearly about the interrelations between variables. Topics covered include the rationale behind the statistical control of third variables, common procedures for statistical control, and what can go wrong during their implementation. Certain types of third variables-colliders and mediators-should not be controlled for because that can actually move the estimate of an association away from the value of the causal effect of interest. More subtle variations of such harmful control include using unrepresentative samples, which can undermine the validity of causal conclusions, and statistically controlling for mediators. Drawing valid causal inferences on the basis of observational data is not a mechanistic procedure but rather always depends on assumptions that require domain knowledge and that can be more or less plausible. However, this caveat holds not only for research based on observational data, but for all empirical research endeavors.