期刊
ENVIRONMENTAL SCIENCE & TECHNOLOGY
卷 49, 期 3, 页码 1888-1895出版社
AMER CHEMICAL SOC
DOI: 10.1021/es505163v
关键词
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资金
- National Natural Science Foundation of China [31100376, 31470554, 41276102]
- Program for Innovative Research Team in University [IRT 13078]
- Shanghai Municipal Education Commission [14YZ001]
- MEL Visiting Fellowship Program
Bisphenol A (BPA) is a well-known environmental endocrine-disrupting chemical. Employing primary macrophages from head kidney of red common carp (Cyprinus carpio), the present study aimed to evaluate the immune modulatory effect of BPA and to explore its potential action mechanism associated with estrogen receptor (ER) and nuclear factor-kappa B (NF-kappa B) pathways. A dynamic response process was observed in macrophages upon various concentrations of BPA exposure, which significantly enhanced the antibacterial activity of macrophages at 0.1, 1, or 10 mu g/L, but instead induced the apoptosis at 100, 1000, and 10 000 mu g/L. A potential pro-inflammatory effect of BPA exposure was suggested, judging from the increased production of nitrite oxide and reactive oxygen species (ROS), the induction of interleukin-1 beta mRNA and protein, as well as NF-kappa B and other NF-kappa B-associated immune gene expression. Following BPA coexposure with the ER or NF-kappa B antagonist, the induction of ROS, ERa, and NF-kappa B-associated immune gene expression was significantly inhibited, implying interaction between those two pathways. This study thus indicated that low doses of BPA exposure alone could significantly disturb the immune response of fish primary macrophages in vitro, and for the first time revealed the synergistic action of ERa and NF-kappa B transcription factors in the BPA effect.
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