期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 75, 期 5, 页码 775-783出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-017-2652-4
关键词
HIV; Interferon; Latency; Anti-viral; JAK/STAT; Cure
资金
- Health Research Board (HRB) [HRA-POR-2012-57] Funding Source: Health Research Board (HRB)
- Health Research Board [HRA_POR/2012/57] Funding Source: Medline
Viral infections, including HIV, trigger the production of type I interferons (IFNs), which in turn, activate a signalling cascade that ultimately culminates with the expression of anti-viral proteins. Mounting evidence suggests that type I IFNs, in particular IFN-alpha, play a pivotal role in limiting acute HIV infection. Highly active anti-retroviral treatment reduces viral load and increases life expectancy in HIV positive patients; however, it fails to fully eliminate latent HIV reservoirs. To revisit HIV as a curable disease, this article reviews a body of literature that highlights type I IFNs as mediators in the control of HIV infection, with particular focus on the anti-HIV restriction factors induced and/or activated by IFN-alpha. In addition, we discuss the relevance of type I IFN treatment in the context of HIV latency reversal, novel therapeutic intervention strategies and the potential for full HIV clearance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据