期刊
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
卷 43, 期 3, 页码 401-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.rdc.2017.04.006
关键词
Axial spondyloarthritis; Ankylosing spondylitis; Genetics; Association; SNP; Heritability
类别
资金
- Abbvie
- Janssen
- Novartis
- Pfizer
- UCB
Ankylosing spondylitis (AS) is a common inflammatory arthritis in which genetic factors are the primary determinants of disease risk and severity. Substantial progress has been made in identifying genetic pathways involved in the disease, and in translating those discoveries to drug discovery programs. Recently discovered novel disease pathways include those involved in control of DNA methylation, bacterial sensing, and mucosal immunity. Additional pathways are likely to be identified as a higher proportion of the genetic risk of AS is determined.
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