期刊
CALCIFIED TISSUE INTERNATIONAL
卷 102, 期 3, 页码 287-295出版社
SPRINGER
DOI: 10.1007/s00223-017-0354-4
关键词
Inflammation; Muscle; Sarcopenia; Strength; Adipokine; Interleukin
资金
- Medical Research Council [MRC_MC_UU_12011/2, MRC_MC_UP_A620_1015]
- University of Southampton UK
- MRC [MC_U147585827, MC_UU_12011/2, MC_UP_A620_1015, G0400491, MR/P021220/1, MR/K00414X/1, MC_U147585819] Funding Source: UKRI
- Medical Research Council [MC_U147585824, MR/K00414X/1, MC_U147585827, G0400491, U1475000001, MC_U147585819, MC_UP_A620_1015, MC_UP_A620_1014, U1475000002, MC_UU_12011/1, MC_UU_12011/2, MR/P021220/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0513-10085, ACF-2016-26-010, NF-SI-0508-10082] Funding Source: researchfish
- Versus Arthritis [19583] Funding Source: researchfish
We investigated the longitudinal relationships between inflammation markers and the following outcomes in a UK cohort study: appendicular lean mass (ALM); walking speed; level and change in grip strength; and sarcopenia defined by the European Working Group on Sarcopenia in Older People. Analyses were based on 336 community-dwelling older men and women (aged 59-70 years) who participated in the Hertfordshire Cohort Study (HCS). Inflammation markers were ascertained at baseline using enzyme-linked immunosorbent assay techniques and Bio-Plex Pro Assays. Grip strength was measured at baseline and follow-up [median follow-up time: 10.8 years (inter-quartile range 10.2-11.6)] and change in grip strength was ascertained using a residual change approach. At follow-up, ALM was ascertained using dual-energy X-ray absorptiometry, customary walking speed was measured and sarcopenia status was ascertained. Gender-adjusted linear and Poisson regression was used to examine the associations between inflammation markers and outcomes with and without adjustment for anthropometric and lifestyle factors. Higher C-reactive protein was associated (p < 0.04) with lower grip strength and accelerated decline in grip strength from baseline to follow-up. Higher cortisol was associated with lower ALM (p < 0.05). Higher interleukin-8 (IL-8) was associated with lower ALM (p < 0.05) and increased risk of sarcopenia [fully-adjusted relative risk per SD increase in IL-8: 1.37 (95% CI 1.10, 1.71), p = 0.005]. All associations were robust in fully-adjusted analyses. Inflammation markers were associated with measures of muscle mass, strength and function in HCS. Further work is required to replicate these associations and to delineate the underlying mechanisms.
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