期刊
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
卷 50, 期 2, 页码 164-170出版社
SCIENCE PRESS
DOI: 10.1093/abbs/gmx135
关键词
FLNa; lung adenocarcinoma; proliferation; metastasis; EGFR
资金
- National Natural Science Foundation of China [81071846]
- Natural Science Foundation of Hebei Province of China [H2013505059]
- Department of Science and Technology of Hebei Province of China [12396107D, 14397707D, 09966114D, 092461102D]
- Wu Jieping Foundation [320.6750.12604, 320.6750.14063, 320.6799.15005]
Filamin A (FLNa) is a ubiquitously expressed cytoplasmic protein, which composes of an N-terminal actin binding domain (ABD) followed by 24 Ig-like repeats. FLNa functions as a cytoskeletal protein that links transmembrane receptors, including integrins, to F-actin and serves as a signaling intermediate. Recent studies have identified FLNa as a scaffold protein that interacts with over 90 proteins and plays vital roles in cellular signaling transduction. Mutations or defects in human FLNa gene have been shown to cause numerous developmental defects. Moreover, aberrant expression of FLNa has been observed in many cancers, such as parathyroid tumor, cervical cancer, and breast cancer. However, its role in lung adenocarcinoma has seldom been discussed. In the present study, our in vitro and in vivo studies demonstrated that silencing FLNa expression in lung cancer cell line A549 cells promoted proliferation, migration, and invasiveness of A549 cells by enhancing the activation of epidermal growth factor receptor and ERK signaling pathway. These results shed light on novel functions of FLNa in lung cancer and uncovered novel mechanisms, these results provided possible targets for the prediction and treatment for lung adenocarcinoma.
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