期刊
BIOMARKERS
卷 23, 期 2, 页码 137-141出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/1354750X.2017.1289241
关键词
miR-200b-3p; oral squamous cell carcinoma; diagnosis; prognosis
Context: Circulating MicroRNAs (miRNAs) are emerging as novel biomarkers for tumour.Objective: Evaluate the diagnostic potential of plasma miR-200b-3p in oral squamous cell carcinoma (OSCC).Materials and methods: miR-200b-3p was detected by qRT-PCR in paired pre-operative and post-operative plasmas from 80 OSCC patients and 80 healthy controls.Results: Plasma miR-200b-3p was significantly upregulated in OSCC, and it was higher in WHO II/III grade than WHO I grade. The AUC of miR-200b-3p for OSCC was 0.9173. miR-200b-3p was significantly downregulated after surgery. High miR-200b-3p expression was associated with poor prognosis.Discussion and conclusion: Plasma miR-200b-3p could be a potential diagnostic biomarker for OSCC.
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