期刊
ENVIRONMENTAL RESEARCH
卷 138, 期 -, 页码 298-305出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2015.02.026
关键词
Prenatal exposure; Endocrine disruption; Mercury; Thyroid; Iodine supplementation
资金
- Instituto de Salud Carlos III [G03/176, CB06/02/0041]
- UE [282957, HEALTH.2010.2.4.5-1]
- FIS FEDER [03/1615, 04/1509, 04/1112, 04/1931, 04/1436, 05/1052, 06/0867, 06/1213, 07/0314, 08/115105/1079, 09/02647, 09/00090, 11/01007, 11/02591, 11/00178, 13/1944, 14/00891, 14/01687]
- Conselleria de Sanitat Generalitat Valenciana, Generalitat de Catalunya [CIRIT 1999SGR 00241]
- Department of Health of the Basque Government [2005111093, 2009111069]
- Provincial Government of Gipuzkoa [DFG06/004, DFG08/001]
Objective: To evaluate the association between mercury exposure and thyroid-stimulating hormone (TSH), total triiodothyronine (TT3) and free thyroxine (FT4) levels during pregnancy as well as to explore if there is any synergic action between mercury and intake of iodine from different sources. Methods: The study population was 1407 pregnant women participating in the Spanish INMA birth cohort study. Total mercury concentrations were analyzed in cord blood. Thyroid hormones (THs) were measured in serum samples collected at 13.2 +/- 1.5 weeks of gestation. The association between mercury and TH levels was evaluated with multivariate linear regression models. Effect modification caused by iodine intake from supplements and diet was also evaluated. Results: The geometric means of TSH, TT3, FT4 and mercury were 1.1 mu U/L, 2.4 nmol/L, 10.5 pmol/L and 7.7 mu g/L, respectively. Mercury levels were marginally significantly associated with TT3 (beta: -0.05; 95%CI: -0.10, 0.01), but were neither associated with TSH nor FT4. The inverse association between mercury and TT3 levels was stronger among the iodine supplement consumers (-0.08; 95%Cl: -0.15, -0.02, interaction p-value=0.07). The association with FT4 followed the same pattern, albeit not significant. Conclusion: Prenatal mercury exposure was inversely associated with TT3 levels among women who took iodine supplements during pregnancy. These results could be of public health concern, although further research is needed. (C) 2015 Elsevier Inc. All rights
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