期刊
CANCER SCIENCE
卷 109, 期 3, 页码 490-496出版社
WILEY
DOI: 10.1111/cas.13393
关键词
angioimmunoblastic T-cell lymphoma; epigenetic regulator; multistep and multilineage tumorigenesis; ras homology family member A; T-cell receptor-signaling
类别
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [JP16K15497]
- Grants-in-Aid for Scientific Research [16H02660, 16K15497] Funding Source: KAKEN
Angioimmunoblastic T-cell lymphoma (AITL) is an age-related malignant lymphoma, characterized by immune system-dysregulated symptoms. Recent sequencing studies have clarified the recurrent mutations in ras homology family member A (RHOA) and in genes encoding epigenetic regulators, tet methyl cytosine dioxygenase 2 (TET2), DNA methyl transferase 3 alpha (DNMT3A) and isocitrate dehydrogenase 2, mitochondrial (IDH2), as well as those related to the T-cell receptor signaling pathway in AITL. In this review, we focus on how this genetic information has changed the understanding of the developmental process of AITL and will in future lead to individualized therapies for AITL patients.
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