4.4 Article

Do penile haemodynamics change in the presence of hydrogen sulphide (H2S) donor in metabolic syndrome-induced erectile dysfunction?

期刊

ANDROLOGIA
卷 50, 期 3, 页码 -

出版社

WILEY
DOI: 10.1111/and.12885

关键词

erectile dysfunction; fructose; hydrogen sulphide; intracavernous pressure; metabolic syndrome

资金

  1. Research Foundation of Dokuz Eylul University [2014.KB.SAG.027]

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Erectile dysfunction (ED) is defined in relation to the metabolic syndrome (metS). Hydrogen sulphide (H2S), a gasotransmitter, has been revealed to get involved in hypertension, insulin secretion and regulation of vascular tone especially in erectile physiology. This study aimed to investigate the effect of H2S on metS-induced ED. Animals were divided into two groups as control and metS, which were fed with standard diet or 60% high-fructose diet for 10weeks respectively. The metS model was evaluated with biochemical analyses, waist circumference/tibia length ratio and HOMA index. Penile hemodynamic parameters were evaluated by the measurement of intracavernous pressure/mean arterial pressure ratio during cavernous nerve stimulation in the presence and absence of intracavernous injection of NaHS (100g/50l) and its control 0.9%NaCl (50l) in both groups. H2S levels were measured in penile tissues by methylene blue assay. H2S levels were significantly decreased in the penile tissues of the metS group. Decreased intracavernous pressure/mean arterial pressure ratio improved after intracavernous administration of NaHS in the metS group. These results suggest the significant role of H2S in the metS-induced erectile dysfunction that could be a new therapeutic target.

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