期刊
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
卷 17, 期 2, 页码 351-366出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s10237-017-0965-8
关键词
Mitral valve; Mitral valve repair; Multi-resolution model; Sparse spectral analysis; Anatomical accuracy; High-fidelity model; Very fast image in-painting
资金
- National Heart, Lung, and Blood Institute of the National Institutes of Health [R01HL119297]
An essential element of cardiac function, the mitral valve (MV) ensures proper directional blood flow between the left heart chambers. Over the past two decades, computational simulations have made marked advancements toward providing powerful predictive tools to better understand valvular function and improve treatments for MV disease. However, challenges remain in the development of robust means for the quantification and representation of MV leaflet geometry. In this study, we present a novel modeling pipeline to quantitatively characterize and represent MV leaflet surface geometry. Our methodology utilized a two-part additive decomposition of the MV geometric features to decouple the macro-level general leaflet shape descriptors from the leaflet fine-scale features. First, the general shapes of five ovine MV leaflets were modeled using superquadric surfaces. Second, the finer-scale geometric details were captured, quantified, and reconstructed via a 2D Fourier analysis with an additional sparsity constraint. This spectral approach allowed us to easily control the level of geometric details in the reconstructed geometry. The results revealed that our methodology provided a robust and accurate approach to develop MV-specific models with an adjustable level of spatial resolution and geometric detail. Such fully customizable models provide the necessary means to perform computational simulations of the MV at a range of geometric accuracies in order to identify the level of complexity required to achieve predictive MV simulations.
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