Microsaccade dysfunction and adaptation in hemianopia after stroke

Background: Besides the reduction of visual field size, hemianopic patients may also experience other poorly understood symptoms such as blurred vision, diplopia, or reduced visual acuity, which may be related to microsaccade function. Objective: To determine (i) if microsaccades are altered in hemianopia; (ii) how altered microsaccade features correlate with visual performances; and (iii) how their direction relates to visual field defect topography. Methods: In this case-control study, microsaccades of hemianopic stroke patients (n = 14) were assessed with high-resolution eye-tracking technique, compared with those of healthy controls (n = 14), and correlated with visual performances, visual field defect parameters and lesion age. Results: Patients' microsaccades had (i) larger amplitude (P = 0.027), (ii) longer duration (P = 0.042), and (iii) impaired binocular microsaccade conjugacy (horizontal: P = 0.002; vertical: P = 0.035). Older lesions were associated with poorer binocular conjugacy (horizontal: r(14) = 0.67, P = 0.009; vertical: r(14) = 0.75, P = 0.002) and larger microsaccade amplitudes (r(14) = 0.55, P = 0.043). (iv) Half of the patients had a microsaccade bias towards the seeing field (monocular: P = 0.002; binocular: P < 0.001) which was associated with faster reactions to super-threshold visual stimuli in areas of residual vision (P = 0.042). Finally, (v) patients with more binocular microsaccades (r(14) = 0.59, P = 0.027) and lower microsaccade velocity (r(14) = -0.66, P = 0.011) had better visual acuity. Conclusions: Hemianopia leads not only to the loss of visual field but also to microsaccade enlargement and impaired binocular conjugacy, suggesting malfunctioning microsaccade control circuits which worsen over time. But a microsaccade bias towards the seeing field, which suggests greater allocation of attention, accelerates stimulus detection. Microsaccades may play a role to compensate for vision impairment and provide a basis for vision restoration and plasticity, which deserves further exploration.