期刊
ARAB JOURNAL OF UROLOGY
卷 16, 期 1, 页码 171-180出版社
TAYLOR & FRANCIS LTD
DOI: 10.1016/j.aju.2017.11.015
关键词
Non-obstructive azoospermia; Fertility preservation; Onco-fertility; Male infertility; Stem cell therapy; Allograft
资金
- American Urology Association New York Section E. Darracott Vaughan, Jr, MD, Research Scholar Award
Objective: To summarise the current state of research into spermatogonial stem cell (SSC) therapies with a focus on future directions, as SSCs show promise as a source for preserving or initiating fertility in otherwise infertile men. Materials and methods: We performed a search for publications addressing spermatogonial stem cell transplantation in the treatment of male infertility. The search engines PubMed and Google Scholar were used from 1990 to 2017. Search terms were relevant for spermatogonial stem cell therapies. Titles of publications were screened for relevance; abstracts were read, if related and full papers were reviewed for directly pertinent original research. Results: In all, 58 papers were found to be relevant to this review, and were included in appropriate subheadings. This review discusses the various techniques that SSCs are being investigated to treat forms of male infertility. Conclusions: Evidence does not yet support clinical application of SSCs in humans. However, significant progress in the in vitro and in vivo development of SSCs, including differentiation into functional germ cells, gives reason for cautious optimism for future research. (C) 2017 Production and hosting by Elsevier B.V. on behalf of Arab Association of Urology.
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