期刊
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
卷 246, 期 -, 页码 39-46出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resp.2017.07.007
关键词
Motor control; Denervation; Transdiaphragmatic pressure; Respiratory; Diaphragm muscle
资金
- National Institutes of Health (NIH) [R01-HL096750]
- NIH [HL105355]
- Mayo Clinic
Injury to nerves innervating respiratory muscles such as the diaphragm muscle results in significant respiratory compromise. Electromyography (EMG) and transdiaphragmatic pressure (Pdi) measurements reflect diaphragm activation and force generation. Immediately after unilateral diaphragm denervation (DNV), ventilatory behaviors can be accomplished without impairment, but Pdi generated during higher force non-ventilatory behaviors is significantly decreased. We hypothesized that 1) the initial reduction in Pdi during higher force behaviors after DNV is ameliorated after 14 days, and 2) changes in Pdi over time after DNV are associated with concordant changes in contralateral diaphragm EMG activity and ventilatory parameters. In adult male rats, the reduced Pdi during occlusion (similar to 40% immediately after DNV) was ameliorated to similar to 20% reduction after 14 days. Contralateral diaphragm EMG activity did not significantly change immediately or 14 days after DNV compared to the pre-injury baseline for any motor behavior. Taken together, these results suggest that over time after DNV compensatory changes in inspiratory related muscle activation may partially restore the ability to generate Pdi during higher force behaviors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据