Prenatal nonylphenol exposure, oxidative and nitrative stress, and birth outcomes: A cohort study in Taiwan

Data concerning the effects of prenatal exposures to nonylphenol (NP) and oxidative stress on neonatal birth outcomes from human studies are limited. A total of 146 pregnant women were studied (1) to investigate the association between prenatal NP exposure and maternal oxidative/nitrative stress bio-markers of DNA damage (8-hydroxy-2'-deoxyguanosine (8-OHdG), 8-nitroguanine (8-NO(2)Gua)) and lipid peroxidation (8-iso-prostaglandin F-2 alpha (8-isoPF(2 alpha)), 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA)) and (2) to explore the associations among oxidative stress biomarkers, NP exposure, and neonatal birth outcomes, including gestational age, birth weight, length, Ponderal index, and head and chest circumferences. NP significantly increased the 8-OHdG and 8-NO(2)Gua levels. All infants born to mothers with urinary 8-OHdG levels above the median exhibited a significantly shorter gestational duration (B-adjusted = 4.72 days; 95% Cl: -8.08 to -136 days). No clear association was found between NP levels and birth outcomes. Prenatal 8-0HdG levels might be a novel biomarker for monitoring fetal health related to NP exposure. (C) 2015 Elsevier Ltd. All rights reserved.