期刊
DEVELOPMENTAL DYNAMICS
卷 247, 期 4, 页码 588-619出版社
WILEY
DOI: 10.1002/dvdy.24612
关键词
neurodevelopmental disorders; maternal immune activation; autism spectrum disorder; schizophrenia; microglia; animal models
Converging lines of evidence from basic science and clinical studies suggest a relationship between maternal immune activation (MIA) and neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. The mechanisms through which MIA increases the risk of neurodevelopmental disorders have become a subject of intensive research. This review aims to describe how dysregulation of microglial function and immune mechanisms may link MIA and neurodevelopmental pathologies. We also summarize the current evidence in animal models of MIA. Developmental Dynamics 247:588-619, 2018. (c) 2017 Wiley Periodicals, Inc.
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