期刊
AGING CELL
卷 17, 期 2, 页码 -出版社
WILEY
DOI: 10.1111/acel.12706
关键词
biological age; biomarkers of aging; CCL2; chemokine; geropathology; monocyte chemoattractant protein-1
资金
- NIH/NIA [P01 AG043376, R24 AG047115, R01 AG038550, T32 AG000057, AG052958, AG053832]
- National Institute of Aging Intramural Research Program, National Institutes of Health [AG000519]
A serum biomarker of biological versus chronological age would have significant impact on clinical care. It could be used to identify individuals at risk of early-onset frailty or the multimorbidities associated with old age. It may also serve as a surrogate endpoint in clinical trials targeting mechanisms of aging. Here, we identified MCP-1/CCL2, a chemokine responsible for recruiting monocytes, as a potential biomarker of biological age. Circulating monocyte chemoattractant protein-1 (MCP-1) levels increased in an age-dependent manner in wild-type (WT) mice. That age-dependent increase was accelerated in Ercc1(-/Delta) and Bubr1(H/H) mouse models of progeria. Genetic and pharmacologic interventions that slow aging of Ercc1(-/Delta) and WT mice lowered serum MCP-1 levels significantly. Finally, in elderly humans with aortic stenosis, MCP-1 levels were significantly higher in frail individuals compared to nonfrail. These data support the conclusion that MCP-1 can be used as a measure of mammalian biological age that is responsive to interventions that extend healthy aging.
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