期刊
CLINICAL RESPIRATORY JOURNAL
卷 12, 期 4, 页码 1518-1525出版社
WILEY
DOI: 10.1111/crj.12699
关键词
levosimendan; pulmonary hypertension; right heart failure
资金
- Project of Shanghai Pulmonary Hospital [fk1409]
- Program of Shanghai Municipal Health and Family Planning Commission [20164Y0108]
- Program of National Natural Science Foundation of China [81600032]
- Science and Technology Commission of Shanghai Municipality [15YF1409700]
BackgroundDespite using vasoactive and pulmonary hypertension (PH) specific therapies, the in-hospital mortality of severe PH with right heart failure (RHF) is high. We conducted a prospective analysis evaluating the efficacy and safety of levosimendan in PH patients with severe acute RHF. MethodsForty-five PH patients hospitalized between January 2016 and November 2016 were recruited into a single arm, prospective, open-label study. Levosimendan was administered at the rate of .05-0.1 g/kg/min, up to a total dose of 12.5 mg. The primary endpoints were changes of World Health Organization Function Class (WHO-FC) and Borg dyspnoea scores. Secondary endpoints included changes in 6-min walk distance (6-MWD), biochemical markers and right heart structure and function together with adverse events on day 7 and incidence of major cardiovascular events (death or readmission due to RHF) on day 30. ResultsForty-five PH patients were enrolled. On the 7th day after levosimendan infusion, seven out of 13 PH patients with WHO-FC IV improved by one class (P=.008). Borg dyspnoea scores, 6-MWD and NT-proBNP improved significantly (P<.001). Compared with baseline, the right atrial transverse dimension, end-systolic eccentricity index and tricuspid annular plane systolic excursion improved significantly (58.813.1 mm vs 53.7 +/- 12.4 mm; 1.50 +/- 0.27 vs 1.38 +/- 0.23; 15.0 (13.0, 16.0) mm vs 15.8 (14.0, 17.4) mm, P<.005, respectively). One patient occurred sudden death after discharge during follow-up. ConclusionsIntravenous levosimendan can effectively improve severe RHF of PH patients in hospital and well tolerated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据