期刊
RESEARCH ON CHEMICAL INTERMEDIATES
卷 44, 期 2, 页码 1149-1160出版社
SPRINGER
DOI: 10.1007/s11164-017-3157-3
关键词
Quinoline; Thiazolidinone; Ultrasound irradiation; Anti-cancer activity
资金
- Council of Scientific and Industrial Research (CSIR), New Delhi, India
Searching for new active molecules against human breast cancer cell line MCF-7, novel quinoline based thiazolidinones has been efficiently synthesized under ultrasound irradiation. The newly synthesized compounds were tested against human breast cancer cell line MCF-7. Compounds P3, P4, and P6 were found to be promising inhibitors of MCF-7 characterized by lower IC50 values in a dose-dependent mode with high specificity against MCF-7 (IC50 of 10 mu M at 24 h). Among all the synthesized compounds, P3, P4, and P6 shows IC50 values 5.38, 5.12, and 0.73 A mu M, respectively, were considered as a potential lead. These lead molecules showed significant anti-cancer activity against human breast cancer cell line MCF-7. Additionally, induction of G2/M cell arrest within 24 h was discovered via flow cytometry analysis. Overall, our data suggest that potent compounds have an inhibitory effect on cell proliferation of MCF-7 through cell cycle arrest, giving it great potential as a future therapeutic reagent for cancers.
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