Fe3O4@ZrO2/SO42-: A recyclable magnetic heterogeneous nanocatalyst for synthesis of -amino carbonyl derivatives and synthesis of benzylamino coumarin derivatives through Mannich reaction

In the present work, we developed an effective protocol for the synthesis of -amino carbonyl compounds and synthesis of benzylamino coumarin derivatives through Mannich type reaction in high yields. Fe3O4@ZrO2/SO42- was employed as an effective heterogeneous nanocatalyst for the Mannich reaction. This research consists of two sections. In first section, -amino carbonyl derivatives were synthesized under solvent-free condition. In the other section, benzylamino coumarin compounds were synthesized at room temperature. The present approach offers several advantages such as short reaction times, low cost, easy work-up, mild reaction conditions, high yields and ease of recovery and reusability of the catalyst without significant loss of activity.