期刊
REPRODUCTIVE TOXICOLOGY
卷 74, 期 -, 页码 94-103出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2017.09.002
关键词
Pregnancy; Cotinine; Smoking; Dose-dependent; Birth weight; Genetic polymorphism
资金
- Japan Ministry of Health, Labour, and Welfare
- Japan Society for the Promotion of Sciences [25253050, 26893002, 16K19243]
- Grants-in-Aid for Scientific Research [26893002, 16K19243, 16H02645, 15K15220] Funding Source: KAKEN
Objectives: We aimed to assess the individual dose-response effects of eight maternal polymorphisms encoding polycyclic aromatic hydrocarbon-metabolizing and DNA-repair genes on prenatal cotinine levels according to infant birth size. Methods: In total, 3263 Japanese pregnant women were assigned to five groups based on plasma cotinine levels during the 8th month of pregnancy, as measured using ELISA (cut-offs: 0.21, 0.55, 11.48, and 101.67 ng/mL). Analyses were performed using multiple linear regression. Results: Birth weight reduction showed a dose-dependent relationship with prenatal cotinine levels (P for trend < 0.001). When considering the specific aromatic hydrocarbon receptor (AHR) (G >A, Arg554Lys; db SNP ID: rs2066853) and X-ray cross-complementing gene 1 (XRCC1) (C> T, Arg194Trp, rs1799782) genotypes, a larger birth weight reduction was noted among infants born to mothers with the highest cotinine level. Conclusion: Infants born to women with specific AHR and XRCC1 genotypes may have higher genetic risks for birth weight reduction. (C) 2017 Elsevier Inc. All rights reserved.
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