期刊
ACS OMEGA
卷 3, 期 1, 页码 1263-1268出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.7b01755
关键词
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资金
- University Grants Commission (UGC), New Delhi, India, under UGC-JRF Fellowship [23/12/2012(ii)EU-V]
- NRF
- Council of Scientific and Industrial Research (CSIR, New Delhi) [02(0293)/17/EMR-I]
Diverse series of isatin-ferrocene conjugates were synthesized via Cu-promoted azide-alkyne cycloaddition reaction with an aim of probing their antiproliferative structure-activity relationship against MCF-7 (estrogen receptor positive) and MDA-MB-231 (triple negative) cell lines. Among the synthesized conjugates, isatin-ferrocenes proved to be more potent against MCF-7, whereas ferrocenylmethoxy-isatins exhibited activity against MDA-MB-231 cell lines. However, the introduction of chalcone moiety among these hybrids resulted in the complete loss of activity against the tested cell lines, as evident by isatin-ferrocenylchalcones. The conjugates 5a and 9c proved to be the most potent among the series against MCF-7 and MDA-MB-213 cell lines, exhibiting IC50 values of 31.62 and 20.26 mu M, respectively.
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