期刊
ACS OMEGA
卷 3, 期 3, 页码 2683-2689出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.8b00052
关键词
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资金
- National Natural Science Foundation of China [21161003, 21364002, 21671046, 21502028, 51562001]
- Guangxi Natural Science Foundation of China [2014GXNSFBA118038, 2017GXNSFGA198004]
- Program for New Century Excellent Talents in University of the Ministry of Education [NCET-13-0743]
- Program for New Century National Hundred, Thousand and Ten Thousand Talent Project of Guangxi
- State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources [CMEMR2015-A02, CMEMR2013-A08, CMEMR2013-A013, CMEMR2017-A08]
In this study, we have evaluated a water-soluble, nontarget reagent and a carrier-free diiron hexacarbonyl complex, [Fe-2{mu-SCH2CH(OH)CH2-(OH)}(2)(CO)(6)] (TG-FeCORM), that can induce the site-specific release of carbon monoxide (CO) in cancer cells triggered by endogenous glutathione (GSH). The releasing rate of CO was dependent on the amount of endogenous GSH. Being the amount of endogenous GSH higher in cancer cells than in normal cells, the CO-releasing rate resulted faster in cancer cells. Moreover, the anti-inflammatory properties related to the intracellular CO release of TG-FeCORM were also confirmed in the living HeLa cells.
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