期刊
CEREBRAL CORTEX
卷 28, 期 4, 页码 1396-1415出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhx339
关键词
barrel cortex model; cortical reorganization; dendritic spine motility; synaptic plasticity
资金
- European Union Seventh Framework Program (FP7) [604102]
- European Union [720270]
- Swiss National Science Foundation [200020_147200]
- Swiss National Science Foundation (SNF) [200020_147200] Funding Source: Swiss National Science Foundation (SNF)
Excitatory synaptic connections in the adult neocortex consist of multiple synaptic contacts, almost exclusively formed on dendritic spines. Changes of spine volume, a correlate of synaptic strength, can be tracked in vivo for weeks. Here, we present a combined model of structural and spike-timing-dependent plasticity that explains the multicontact configuration of synapses in adult neocortical networks under steady-state and lesion-induced conditions. Our plasticity rule with Hebbian and anti-Hebbian terms stabilizes both the postsynaptic firing rate and correlations between the pre- and postsynaptic activity at an active synaptic contact. Contacts appear spontaneously at a low rate and disappear if their strength approaches zero. Many presynaptic neurons compete to make strong synaptic connections onto a postsynaptic neuron, whereas the synaptic contacts of a given presynaptic neuron co-operate via postsynaptic firing. We find that cooperation of multiple synaptic contacts is crucial for stable, long-term synaptic memories. In simulations of a simplified network model of barrel cortex, our plasticity rule reproduces whisker-trimming-induced rewiring of thalamocortical and recurrent synaptic connectivity on realistic time scales.
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