期刊
RADIOTHERAPY AND ONCOLOGY
卷 122, 期 2, 页码 267-273出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.radonc.2016.11.020
关键词
Zr-89-cetuximab; EGFR; Immuno-PET; Phase I trial
资金
- CTMM framework (AIRFORCE)
- EU 6th and 7th framework program (Euroxy, Metoxia and ARTFORCE)
- Kankeronderzoekfonds Limburg (Health Foundation Limburg)
- National Institute of Health [NIH-USA U01 CA 143062-01]
- Dutch Cancer Society [KWF UM 2008-4210, 2009-4454, 2011-5020, KWF MAC 2013-6425]
Background and purpose: PET imaging of cetuximab uptake may help selecting cancer patients with the highest chance of benefit. The aim of this phase I trial was to determine the safety of the tracer (89)zr-cetuximab and to assess tumour uptake. Methods: Two dose schedules were used; two consecutive doses of 60 MBq Zr-89-cetuximab or a single dose of 120 MBq, both preceded by 400 mg/m(2) of unlabelled cetuximab. Toxicity (CTCAE 3.0) was scored twice weekly. PET-CT scans were acquired on days 4, 5 and 6 (step 1) or 5, 6, 7 (step 2). Because tumour uptake could not be assessed satisfactorily, a third step was added including EGFR overexpressing tumours. Results: Nine patients were included (6 NSCLC; 3 HNC). No additional toxicity was associated with administration of 89Zr-cetuximab compared to standard cetuximab. A tumour to blood ratio (TBR) > 1 was observed in all but one patient, with a maximum of 4.56. TBR was not different between dose schedules. There was a trend for higher TBR at intervals > 5 days after injection. Conclusions: Both presented 89Zr-cetuximab administration schedules are safe. The recommended dose for future trials is 60 MBq, with a minimum time interval for scanning of 6 days. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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