期刊
RADIOTHERAPY AND ONCOLOGY
卷 122, 期 2, 页码 242-247出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.radonc.2016.12.008
关键词
Positron Emission Tomography; Image Segmentation; Intensity Modulated Radiation Therapy; Automatic PET segmentation
资金
- Cancer Research Wales [7061, 2476]
Purpose: To evaluate the feasibility and impact of using a novel advanced PET auto-segmentation method in Head and Neck (H&N) radiotherapy treatment (RT) planning. Methods: ATLAAS, Automatic decision Tree-based Learning Algorithm for Advanced Segmentation, previously developed and validated on pre-clinical data, was applied to F-18-FDG-PET/CT scans of 20 H&N patients undergoing Intensity Modulated Radiation Therapy. Primary Gross Tumour Volumes (GTVs) manually delineated on CT/MRI scans (GTVp(CT/MRI)), together with ATLAAS-generated contours (GTVp(ATLAAs)) were used to derive the RT planning GTV (GTVp(final)), ATLAAS outlines were compared to CT/MRI and final GTVs qualitatively and quantitatively using a conformity metric. Results: The ATLAAS contours were found to be reliable and useful. The volume of GTVp(ATLAAS), was smaller than GTVp(CT/MRI) in 70% of the cases, with an average conformity index of 0.70. The information provided by ATLAAS was used to grow the GTVp(CT/MRI), in 10 cases (up to 10.6 mL) and to shrink the GTVp(CT/MRI) in 7 cases (up to 12.3 mL). ATLAAS provided complementary information to CT/MRI and GTVpATLAAs contributed to up to 33% of the final GTV volume across the patient cohort. Conclusions: ATLAAS can deliver operator independent PET segmentation to augment clinical outlining using CT and MRI and could have utility in future clinical studies. (C) 2017 Elsevier B.V. All rights reserved. Radiotherapy and Oncology 122 (2017) 242-247
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据