期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 82, 期 4, 页码 689-697出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09168451.2017.1401916
关键词
Bifidobacterium adolescentis; quercetin; anti-inflammatory activity; culture supernatant; bioactive substances
类别
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [22780120, 26850085]
- Food Science Institute Foundation (Ryoushoku-kenkyukai), Japan
- Grants-in-Aid for Scientific Research [26850085, 22780120] Funding Source: KAKEN
The genus Bifidobacterium is well known to have beneficial health effects. We discovered that quercetin and related polyphenols enhanced the secretion of anti-inflammatory substances by Bifidobacterium adolescentis. This study investigated characteristics of the anti-inflammatory substances secreted by B. adolescentis. The culture supernatant of B. adolescentis with quercetin reduced the levels of inflammatory mediators in activated macrophages. Spontaneous quercetin degradant failed to increase anti-inflammatory activity, while the enhancement of anti-inflammatory activity by quercetin was sustained after washout of quercetin. Physicochemical treatment of the culture supernatant indicated that its bioactive substances may be heat-stable, non-phenolic, and acidic biomolecules with molecular weights less than 3kDa. Acetate and lactate have little or no effect on nitric oxide production. Taken together, the anti-inflammatory substances secreted by B. adolescentis may be small molecules but not short chain fatty acids. In agreement with these findings, stearic acid was tentatively identified as a bioactive candidate compound.
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