期刊
BIOMEDICAL REPORTS
卷 8, 期 1, 页码 37-40出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/br.2017.1011
关键词
proteoglycan; salmon nasal cartilage; transplantation; skin graft; anti-inflammation
资金
- Ministry of Education, Culture, Sports, Science and Technology City Area Program for the Promotion of Science and Technology in Regional Areas (Japan)
- Grants-in-Aid for Scientific Research [16H05185] Funding Source: KAKEN
Proteoglycan (PG) is a complex glycohydrate that is widely distributed in the extracellular matrix. Oral administration of PG extracted from salmon nasal cartilage has been reported to attenuate the severity and proinflammatory cytokine responses in mouse experimental colitis, autoimmune encephalomyelitis, collagen-induced arthritis and obesity-induced inflammation. In the present study, the effects of salmon nasal cartilage PG on skin allografts were investigated in a mouse model. Oral administration of PG prolonged the survival of skin grafts within 10 days of transplantation. Although PG failed to inhibit allograft rejection at the final stage of transplantation, PG attenuated the cell infiltration in the skin under the transplanted site.
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