期刊
RADIOLOGY
卷 283, 期 1, 页码 215-221出版社
RADIOLOGICAL SOC NORTH AMERICA (RSNA)
DOI: 10.1148/radiol.2016152679
关键词
-
资金
- NIHR Clinician Scientist Fellowship [NIHR/CS/009/011]
- Chang Gung Medical Foundation
- Chang Gung Memorial Hospital
- Commonwealth Scholarship Commission
- Cambridge Commonwealth Overseas Trust
- NIHR Cambridge Biomedical Research Centre
- National Institute for Health Research (NIHR)
- National Institute for Health Research [NIHR/CS/009/011] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [NIHR/CS/009/011] Funding Source: National Institutes of Health Research (NIHR)
Purpose: To explore the diffusion-tensor (DT) imaging-defined invasive phenotypes of both isocitrate dehydrogenase (IDH-1)-mutated and IDH-1 wild-type glioblastomas. Materials and Methods: Seventy patients with glioblastoma were prospectively recruited and imaged preoperatively. All patients provided signed consent, and the local research ethics committee approved the study. Patients underwent surgical resection, and tumor samples underwent immunohistochemistry for IDH-1 R132H mutations. DT imaging data were coregistered to the anatomic magnetic resonance study and reconstructed to provide the anisotropic and isotropic components of the DT. The invasive phenotype was determined by using previously published criteria and correlated with IDH-1 mutation status by using the Freeman-Halton extension of the Fisher exact probability test. Results: Nine patients had an IDH-1 mutation and 61 had IDH-1 wild type. All of the patients with IDH-1 mutation had a minimally invasive DT imaging phenotype. Among the IDH-1 wild-type tumors, 42 of 61 (69%) were diffusively invasive glioblastomas, 14 of 61 (23%) were locally invasive, and five of 61 (8%) were minimally invasive (P < .001). Conclusion: IDH-mutated glioblastomas have a less invasive phenotype compared with IDH wild type. This finding may have implications for individualizing the extent of surgical resection and radiation therapy volumes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据