期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 4, 页码 1068-1072出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201711397
关键词
cascade reactions; kinetic resolution; organocatalysis; photochemistry; radicals
资金
- Generalitat de Catalunya (CERCA Program)
- Agencia Estatal de Investigacion (AEI) [CTQ2016-75520-P]
- Agencia Estatal de Investigacion (Severo Ochoa Excellence Accreditation) [SEV-2013-0319]
- European Research Council (ERC) [681840-CATA-LUX]
- ICIQ-LMU [SEV-2013-0319]
Reported herein is a photochemical cascade process that combines the excited-state and ground-state reactivity of chiral organocatalytic intermediates. This strategy directly converts racemic cyclopropanols and alpha,beta-unsaturated aldehydes into stereochemically dense cyclopentanols with exquisite stereoselectivity. Mechanistic investigations have enabled elucidating the origin of the stereoconvergence, which is governed by a kinetic resolution process.
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