期刊
RADIATION ONCOLOGY
卷 12, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/s13014-017-0795-y
关键词
Autophagy; Radiotherapy; Signalling pathway; Radiotherapy efficacy; Radiosensitivity; Cancer Cell lines
资金
- The Hong Kong Polytechnic University Postgraduate Studentship
Autophagy is an important catabolic process in which cells digest and recycle their own cytoplasmic contents for maintaining cellular homeostasis. Interestingly, autophagy could play both pro-death and pro-survival roles in influencing the development of cancer via various signal pathways. As radiotherapy is one of the main treatment modalities for cancer, we reviewed the effect of autophagy modulations on radiosensitivity and radiotherapy efficacy in various cancer types. The future development of autophagy modifications for improving radiotherapy efficacy and cancer prognosis will also be discussed.
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