Measurement and simulation of secondary neutrons from uniform scanning proton beams in proton radiotherapy

It has long been known that exposure from secondary neutrons in proton radiotherapy can lead to increased risk of secondary cancers later in a patient's life. The assessment of secondary neutrons is, therefore, important to the overall quality of the treatment. In this study, we investigated the neutron dose equivalent outside of the primary proton treatment field as a function of distance to the isocenter and angle relative to the central axis. CR-39 plastic nuclear track detectors (PNTD) were exposed to uniform scanning proton beams at the ProCure Proton Therapy Center, Oklahoma City, OK. The contribution of neutron dose equivalent was investigated for two different experimental configurations, namely hollow -phantom, and cylindrical -phantom. Numerical simulations were performed using the Monte Carlo code FLUKA for similar experimental conditions. Three proton beams of range 5 cm, 18 cm, and 32 cm with 4 cm modulation width, 38 cm snout to phantom surface distance and a 5 cm diameter aperture were used for the study. The measured ratio of neutron dose equivalent to the primary proton dose (H/D) fell off with distance and ranged from 2.1 mSv/Gy to 50.1 mSv/Gy. The contribution of internal neutrons to the overall neutron dose equivalent were found to be up to 64% near the treatment field. (C) 2016 Elsevier Ltd. All rights reserved.