期刊
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 79, 期 4, 页码 -出版社
WILEY
DOI: 10.1111/aji.12786
关键词
immunosuppression; indoleamine-2; 3-dioxygenase; normal pregnancy; preeclampsia; preterm labor; recurrent spontaneous abortion
资金
- National Basic Research Program of China [2015CB943300]
- Oriented Project of Science and Technology Innovation from Key Lab. of Reproduction Regulation of NPFPC [CX2017-2]
- Program for Zhuoxue of Fudan University
- Development Fund of Shanghai Talents [201557]
- Shanghai Rising-Star Program [16QA1400800]
- National Natural Science Foundation of China (NSFC) [31671200, 8149044, 91542108, 81471548, 81471513]
The survival of allogeneic fetus during pregnancy contradicts the laws of immune responses. Behind this paradoxical phenomenon, the mechanism is quite complex. Indoleamine-2,3-dioxygenase (IDO) is the first and rate-limiting enzyme of tryptophan catabolism. Emerging evidence shows that IDO is expressed at the maternal-fetal interface, including trophoblast cells, decidual stroma cells, decidual immune cells (eg, natural killer cells, T cells, and macrophages), and vascular endothelial cells of decidua and chorion. Moreover, the expression and activity of IDO are different among non-pregnant, normal pregnant, and pathological pregnant conditions. IDO plays important roles in normal pregnancy through immune suppression and regulation of fetal invasion and circulation. However, the abnormal expression and dysfunction of IDO are associated with some pathological pregnancies (including recurrent spontaneous abortion, preeclampsia, preterm labor, and fetal growth restriction).
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