期刊
CLINICAL PEDIATRICS
卷 57, 期 4, 页码 421-427出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0009922817729482
关键词
folic acid; maternal diet; pediatric; asthma; airway inflammation
类别
资金
- National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID) [R01AI102960, R01 HD034568, R01 HL111108, T32 HL007427, R01 HL 064925]
Prenatal folic acid exposure has been linked to higher risk of childhood asthma in countries that do not fortify the food supply with folic acid. This study seeks to examine this association in the United States, where the food supply is generally fortified with folic acid. Participants were 1279 mother-child pairs from Project Viva, an ongoing prospective birth cohort, with folic acid intake in pregnancy assessed through validated food frequency questionnaires. The primary outcome was physician-diagnosed asthma at mid-childhood. In an unadjusted logistic regression model, higher folic acid intake was associated with lower odds of asthma in mid-childhood (odds ratio [OR] 0.48; 95% CI 0.31-0.76). However, in the adjusted analysis this association was attenuated (adjusted OR [aOR] 0.80; 95% CI 0.49-1.33). Our results suggest that in the United States, where there is generalized folic acid fortification of food, maternal folic acid intake during pregnancy is not associated with asthma development in offspring.
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