期刊
DIABETES
卷 67, 期 3, 页码 518-531出版社
AMER DIABETES ASSOC
DOI: 10.2337/db17-0934
关键词
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资金
- National Natural Science Foundation of China [81500647, 81471039, 81270893]
- Natural Science Foundation Project of Chongqing [CSTC2016jcyjA0502, CSTC2014jcyjjq10006, CSTC2012jjB10023]
- Third Military Medical University miaopu cultivation project
- Clinical Research Project of Xinqiao Hospital of Third Military Medical University [2016YLC15]
Patients with diabetes often experience multiple disease complications. Hypoglycemic agents can have both positive and negative effects on diabetic complications, which should be carefully assessed when personalized treatment strategies are developed. In this study we report that dipeptidyl peptidase 4 inhibitors ( DPP-4is), a group of widely used antihyperglycemic agents, can improve diabetic wound healing, independent of their beneficial effects on glycemic control. In particular, DPP-4is promoted the migration and epithelial-mesenchymal transition of keratinocytes, directly and indirectly, by inducing stromal cell-derived factor 1 alpha production of fibroblasts in vitro and in diabetic mice. In addition, DPP-4is attenuated collagen synthesis and deposition, which may diminish scar formation. Furthermore, the results of a randomized clinical trial ( NCT02742233) involving 67 patients with type 2 diabetes supported the role of DPP-4i treatment in diabetic wound healing. Our findings support the application of DPP-4i as a preferred option for treating ulcers in patients with diabetes.
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