期刊
NATURE REVIEWS IMMUNOLOGY
卷 18, 期 5, 页码 309-324出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri.2017.142
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资金
- Japan Society for the Promotion of Science (JSPS)
- Uehara Memorial Foundation Fellowship
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Kanae Foundation for the Promotion of Medical Science
- JSPS KAKENHI [JP15K21775]
- 'Kibou' Projects
- Astellas Foundation for Research on Metabolic Disorders
- SENSHIN Medical Research Foundation
- Bristol-Myers Squibb
- SGH foundation
- MSD Life Science Foundation
- Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care
- Yasuda Medical Foundation
- Suzuken Memorial Foundation
- Pancreas Research Foundation of Japan
- Waksman Foundation of Japan Inc.
- Japanese Foundation for Multidisciplinary Treatment of Cancer
- Toray Science Foundation
- Project Mirai Cancer Research Grants from the Japan Cancer Society
- Princess Takamatsu Cancer Research Fund
- Takeda Science Foundation
- US National Institutes of Health [AI043477, CA219119, CA155120, CA118165]
Fourteen years have passed since nuclear factor-kappa B (NF-kappa B) was first shown to serve as a molecular lynchpin that links persistent infections and chronic inflammation to increased cancer risk. The young field of inflammation and cancer has now come of age, and inflammation has been recognized by the broad cancer research community as a hallmark and cause of cancer. Here, we discuss how the initial discovery of a role for NF-kappa B in linking inflammation and cancer led to an improved understanding of tumour-elicited inflammation and its effects on anticancer immunity.
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