期刊
BIOMEDICAL MATERIALS
卷 13, 期 3, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1748-605X/aa9f01
关键词
collagen; basic fibroblast growth factor; collagen-binding domain; corpus spongiosum; urethral regeneration
资金
- National Key R&D Program of China [2016YFC1000807, 2016YFC1000800, 2016YFC1000801, 2016YFC1000802]
Regeneration of the corpus spongiosum helps prevent complications following urethral reconstruction, but currently there is a lack of effective therapeutic methods in clinic. In previous studies, we fabricated a fusion protein collagen-binding domain (CBD)-basic fibroblast growth factor (bFGF) that specifically binds to and releases from collagen biomaterials. We demonstrated that CBD-bFGF could promote angiogenesis and tissue regeneration in vivo. In this study, we established a beagle model with extensive urethral defects, and reconstructed the defects with collagen biomaterials that were unmodified or modified with CBD-bFGF. The results demonstrate that CBD-bFGF promotes corpus spongiosum regeneration resulting in improved outcomes following urethral reconstruction. Modifying collagen biomaterials with CBD-bFGF may represent an effective strategy for urethral substitution in urethral reconstruction.
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